发明名称 |
A THERMOREVERSIBLE PHARMACEUTICAL FURMULATION FOR ANTI-MICROBIAL AGENTS COMPRISING POLOXAMER POLYMERS AND HYDROXY FATTY ACID ESTER OF POLYETHYLENE GLYCOL |
摘要 |
The present invention provides a pharmaceutical formulation having thermoreversible properties, comprising: a) an anti-microbial agent; b) a poloxamer mixture containing at least two poloxamer polymers; and c) a hydroxy fatty acid ester of polyethylene glycol, wherein the formulation is a solid at room temperature and is a liquid-gel at body temperature. The thermoreversible pharmaceutical formulation has a viscosity of about 8,500 cP to about 400,000 cP at room temperature, and a viscosity of about 1,000 cP to about 8,000 cP at body temperature and exhibits a hysteresis loop behavior. The present invention further provides a process of preparing as well as a method of treating a microbial infection in a mammal using the same. |
申请公布号 |
WO2006024138(A1) |
申请公布日期 |
2006.03.09 |
申请号 |
WO2005CA01254 |
申请日期 |
2005.08.16 |
申请人 |
TARO PHARMACEUTICAL INDUSTRIES LTD. |
发明人 |
GEORGEWILL, DAWAYE, A.;MODENHAUER, MAXINE, G.;FELDMAN, TERRY |
分类号 |
(IPC1-7):A61K31/705;A61K47/30;A61K9/02;A61P31/04 |
主分类号 |
(IPC1-7):A61K31/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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