METHOD FOR MAINTAINING PLURIPOTENCY OF STEM/PROGENITOR CELLS
摘要
<p>The present invention relates to a method for maintaining pluripotency and/or self-renewing characteristics of stem/progenitor cells. The invention also relates to a method for modulating gene expression in a cell. The methods include contacting at least two transcription factors, or a functional fragment thereof, with the promoter region of the nanog gene. One of the at least two transcription factors is selected from the POU- and homeo-domain-containing transcription factors. Another of the at least two transcription factors is selected from the HMG domain-containing transcription factors. The method further comprises allowing the at least two transcription factors to form a complex with a specific binding element within the nanog promoter. The complex thus formed regulates nanog gene expression by mediating transcriptional activation.</p>
申请公布号
WO2006025802(A1)
申请公布日期
2006.03.09
申请号
WO2005SG00304
申请日期
2005.09.02
申请人
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;ROBSON, PAUL;RODDA, DAVID;NG, HUCK HUI