METHOD

摘要

The present invention relates to inter alia a method for identifying compact and/or open chromatin in a sample comprising the steps of: (a) preparing a plurality of chromatin fragments; (b) sedimenting the chromatin fragments into one or more fractions; (c) resolving at least one of the fractions into chromatin fragments of different lengths; and (d) isolating one or more DNA fragments that are shorter and/or longer than bulk chromatin; wherein DNA fragments that are shorter than bulk chromatin correspond to compact chromatin and wherein DNA fragments that are longer than bulk chromatin correspond to open chromatin.