DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH MIXED LINEAGE KINASE 4 ALPHA (MLK4 ALPHA)

摘要

The invention provides a human MLK4 alpha which is associated with cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of MLK4 alpha as well as pharmaceutical compositions comprising such compounds.