METHOD OF MANUFACTURING MICROCAPSULES

摘要

Described is a method of manufacturing microcapsules from biodegradable polymers, the method using biodegradable solvents and producing microcapsules which are free from toxic solvent residues. The solvents used include simple esters made from a C1-C5 alcohol and a C1-C5 monocarboxylic acid, as well as mixtures of such esters, and the solvent can also contain a C1-C5 alcohol. Both water-soluble and water-insoluble active substances can be incorporated in the microcapsules. Water-soluble active substances such as drugs, peptides, proteins, enzymes and vaccins are preferably dispersed as an aqueous solution in the polymer solution. The microcapsules are produced by spraying a solution, suspension or water-in-oil dispersion of active substances and biodegradable polymers. The method is suitable for use in the manufacture of drug, vaccin and enzyme preparations.