发明名称 |
A PHARMACEUTICAL COMPOSITION FOR CONTROLLED RELEASE OF A BETA-LACTAM ANTIBIOTIC |
摘要 |
<p>An improved stable pharmaceutical composition for controlled release of an active ingredient comprises a betalactam antibiotic such as cephalexin, cefaclor or their pharmaceutically acceptable hydrates, salts or esters as active ingredient, a calcium salt and a mixture of hydrophilic polymers selected from the group consisting of at least one sodium alginate and one xanthan gum and with or without hydroxypropyl methylcellulose, said composition optionally containing probenecid. The composition may also contain one or more of a water soluble and/or water dispersible diluent, wherein the quantities of the hydrophilic polymers and water soluble and/or water dispersible diluents are such that the therapeutically effective active ingredient is released at a rate suitable for once or twice daily administration of the pharmaceutical composition.</p> |
申请公布号 |
EP1461017(B1) |
申请公布日期 |
2006.03.08 |
申请号 |
EP20010274758 |
申请日期 |
2001.11.19 |
申请人 |
LUPIN LIMITED |
发明人 |
SEN, HIMADRI;KSHIRSAGAR, RAJESH SURESH;BHAMARE, SHAILESH SURESH |
分类号 |
A61K9/22;A61K9/20;A61K9/24;A61K31/24;A61K31/545;A61K33/06 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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