| 摘要 |
Aminoalkyl-substd. cpds. of formula( (X);-(core moiety) (I) are new j=1-3; (core moiety) = a non-cyclic, cyclic or heterocyclic moiety, where a cyclic or heterocyclic core moiety comprises at least one 4-7-membered ring; x= a racemic mixt, R or S enantiomer, solvate, hydrate or salt of R1R2N-(CH2)n-*CH(OR3)-(CH2)-m (II) or (III) *C= a chiral C atom; n=1-4; one or more C atoms of (CH2)n may be substd. by a keto or OH gp, m=4-14; R1R2=H, alkane or alkene of up to 12C or (CH2)wR5; or jointly R1 and R2 form a substd. or unsubstd. satd. or unsatd. heterocyclic gp. of 4-8C w=2-14; R5=mono-, di- or tri-substd. or unsubstd. aryl gp. substits. on R5 being selected from OH,Cl,F,Br or 1-6C alkoxy; R3= H or 1-3C alkyl; R4=H, alkane or alkene of up to 8C, (CH2)wR5 or a substd. or unsubstd. satd, or unsatd. heterocyclic gp. having 4-8C; r,s=1-4; (r+s) is not greater than 5; t=1-14; one or more C atoms of (CH2)s or (CH2)t may be substd. by a keto or OH gp.
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