(2-azabicyclo[2.2.1]hept-7yl) methanol derivatives as nicotinic acetylcholine receptor agonists

摘要

The present invention relates to substances of the general formula (I) in which X is selected from the group consisting of NH, NR⁴, O and S, R¹ is selected from the group consisting of hydrogen, linear and branched, substituted and unsubstituted C₁-C₁₀-alkyl groups, substituted and unsubstituted C₅-C₁₀-aryl groups, substituted and unsubstituted C₄-C₁₀-heteroaryl groups, acyl groups, thioacyl groups, carbonylcarboxy groups, N-organyl-substituted carbamoyl groups and organosulfonyl groups, R², R³ are selected, independently of one another, from the group consisting of C₁-C₁₀-alkyl groups, C₅-C₁₂-aryl groups and C₄-C₁₂-heteroaryl groups, these groups being unsubstituted or having one or more substituents which are selected, independently of one another, from the group consisting of halogens, alkoxy groups, aryloxy groups, nitro groups, C₁-C₅-alkoxycarbonyl groups, optionally fluorine-substituted alkyl or acyl groups and cyano groups, R⁴ is selected from the group consisting of hydrogen, linear and branched, substituted and unsubstituted C₁-C₁₀-alkyl groups, substituted and unsubstituted C₅-C₁₀-aryl groups, substituted and unsubstituted C₄-C₁₀-heteroaryl groups, aryl groups, thioacryl group, carbonylcarboxy groups, N-organyl-substituted carbamoyl groups and organosulfonyl groups, or a physiologically acceptable salt thereof.