| 摘要 |
<p>Compositions and methods for administration of a bio-affecting catalyst, such as an enzyme, are provided. The compositions comprise at least one enzyme or other bio-affecting catalyst, retained within a matrix. The matrix provides a barrier between the entrapped enzyme and external degradative enzymes or cellular defense systems of a patient's body, and also prevents release of the enzyme. The matrix comprises pores or channels to enable entry and exit of substrates and products. Preferably, the matrix is a high viscosity cubic phase of one or more suitable amphiphilic compounds, such as glyceryl monooleate. Preferred methods of the invention comprise formulating the composition as an injectable low viscosity phase, which undergoes phase transition upon exposure to physiological conditions.</p> |
