发明名称 |
NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE |
摘要 |
The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention. |
申请公布号 |
YU56903(A) |
申请公布日期 |
2006.03.03 |
申请号 |
YU2003P000569 |
申请日期 |
2002.01.18 |
申请人 |
MERCK & CO.INC.;ISIS PHARMACEUTICALS INC. |
发明人 |
CARROLL, STEVEN S.;MACCOSS, MALCOLM;OLSEN, DAVID B.;BHAT, BALKRISHEN;BHAT, NEELIMA;COOK, PHILLIP DAN;ELDRUP, ANNE B.;PRAKASH, THAZHA P.;PRHAVC, MARIJA;SONG, QUANLAI |
分类号 |
C07D487/04;A61K31/519;A61K31/70;A61K31/7052;A61K31/706;A61K31/7064;A61K31/7068;A61K31/7076;A61K31/708;A61K31/7105;A61K31/712;A61K38/21;A61K45/00;A61K45/06;A61P1/16;A61P31/14;A61P43/00;C07D473/00;C07D487/02;C07H;C07H19/00;C07H19/04;C07H19/048;C07H19/06;C07H19/067;C07H19/09;C07H19/10;C07H19/14;C07H19/16;C07H19/167;C07H19/173;C07H19/19;C07H19/20;C12N |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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