BENZOPHENANTHROLINES AND RELATED FUSED ACRIDINES BENZOPHENANTHROLINES AND RELATED FUSED ACRIDINES

摘要

7-amino-5,6-dihydrobenzo[b][1,7]phenanthroline (compound MAM 102; Figure 1), or related fused acridines, are prepared by the condensation of A and B under dehydration conditions. 7-amino[b][1,7]phenanthroline (compound MAM 58, Figure 2), or similar related fused acridines, are then prepared by dehydrogenation of the condensation product. The compounds are inhibitors of protein tyrosine kinases and can be used in pharmaceutical formulations for the treatment of mammalian carcinomas.