NOVEL METHOD FOR SYNTHESIS OF N-/(S)-1-CARBOXYBUTYL/-(S)- ALANINE ESTERS AND USE IN SYNTHESIS OF PERINDOPRIL

摘要

The invention concerns a stereoselective method for industrial synthesis of derivatives of formula (I) wherein: R represents a linear or branched C1-C6 alkyl group, from S-norvalinate ethyl and sodium pyruvate. The invention is useful for the synthesis of perindopril and pharmaceutically acceptable salts thereof.