OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS
摘要
Chemokine receptor antagonists, in particular, 3,7-diazabicyclo [3.3.0] octane compounds according to formula (I) are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are allieviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula (I).
申请公布号
WO2005121145(A3)
申请公布日期
2006.03.02
申请号
WO2005EP05895
申请日期
2005.06.01
申请人
F. HOFFMANN-LA ROCHE AG;LEE, EUN, KYUNG;MELVILLE, CHRIS, RICHARD;ROTSTEIN, DAVID, MARK
发明人
LEE, EUN, KYUNG;MELVILLE, CHRIS, RICHARD;ROTSTEIN, DAVID, MARK