MEDIUM FOR THE REDIFFERENTIATION OF DEDIFFERENTIATED CHONDROCYTES INTO CHONDROCYTES

摘要

It is intended to provide a medium for the redifferentiation of dedifferentiated chondrocytes into chondrocytes and a method of redifferentiating dedifferentiated chondrocytes into chondrocytes whereby dedifferentiated chondrocytes, which have been dedifferentiated by, for example, culturing in vitro and thus show weakened chondral characteristics, can be efficiently and easily redifferentiated into the original chondrocytes. That is to say, a medium for the redifferentiation of dedifferentiated chondrocytes into chondrocytes which is to be used for redifferentiating dedifferentiated chondrocytes having been dedifferentiated and thus showing weakened chondral characteristics into the original chondrocytes and contains insulin together with at least one member selected from among BMP-2 and its analogs; and a method of redifferentiating dedifferentiated chondrocytes into the original chondrocytes by culturing the dedifferentiated chondrocytes with the use of the medium for the redifferentiation of dedifferentiated chondrocytes into chondrocytes. In a preferred embodiment, the above-described medium for the redifferentiation of dedifferentiated chondrocytes into chondrocytes further contains T3.