IMPFSTOFFZUBEREITUNG BESTEHEND AUS UNTEREINHEITEN DES RESPIRATORISCHEN SYNZYTIALVIRUS (RSV)

摘要

The fusion (F) protein, attachment (G) protein and matrix (M) protein of respiratory syncytial virus (RSV) are isolated and purified from respiratory syncytial virus by mild detergent extraction of the proteins from concentrated virus, loading the protein onto a hydroxyapatite or other ion-exchange matrix column and eluting the protein using mild salt treatment. The F, G and M proteins, formulated as immunogenic compositions, are safe and highly immunogenic and protect relevant animal models against disease caused by respiratory syncytial virus infection.