DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH 5-HYDROXYTRYPTAMINE RECEPTOR 3B (5-HT3B)

摘要

The invention provides a human 5-HT3b which is associated with the dermatological diseases, gastroenterological diseases, cancer, metabolic diseases, cardiovascular diseases, hematological diseases, inflammation, respiratory diseases, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of dermatological diseases, gastroenterological diseases, cancer, metabolic diseases, cardiovascular diseases, hematological diseases, inflammation, respiratory diseases, neurological diseases, urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of 5-HT3b as well as pharmaceutical compositions comprising such compounds.