发明名称 |
STABILIZED IMMUNOMODULATORY OLIGONUCLEOTIDES. |
摘要 |
<p>The invention provides immunostimulatory oligonucleotides having at least one CpG dinucleotide and a secondary structure at the 5' -or 3'-end. These oligonucleotides have either reduced or improved immunostimulatory properties. The invention establishes that 5'-terminal secondary structures affect immunostimulatory activity significantly more than those at the 3'-end. The invention also provides methods for increasing or decreasing the immunostimulatory activity of a CpG-containing nucleic acid.</p> |
申请公布号 |
MXPA05013658(A) |
申请公布日期 |
2006.03.02 |
申请号 |
MX2005PA13658 |
申请日期 |
2004.06.10 |
申请人 |
HYBRIDON, INC. |
发明人 |
PANDEY, RAJENDRA K. |
分类号 |
A01N43/04;A61K31/70;A61K48/00;C07H21/02;C07H21/04;C12N;(IPC1-7):A01N43/04;C12N00/00 |
主分类号 |
A01N43/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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