| 摘要 |
<p>A method for delivering a pharmaceutical composition to a human or animal nail, said method comprising forming several partial orifices in a nail with an appropriate device and applying a pharmaceutical composition in the orifices. Preferably the device comprises a laser programmed in a way to drill arrays of partial orifices where each partial orifices can be drilled with a single laser shot or, optionally with several laser shots. Preferably the partial orifices have similar depths across the nail. The method of the invention allows for the continuous treatment of diseases over a period of time with a minimum of patient discomfort combined with a high degree of efficacy.</p> |
