TRAF FAMILY MOLECULE, POLYNUCLEOTIDE CODING FOR THE MOLECULE, AND ANTIBODY AGAINST THE MOLECULE

摘要

A novel TRAF family molecule, a polynucleotide coding for the molecule, an antibody against the molecule, and an antisense polynucleotide of the molecule. The base sequence of a gene of an unknown TRAF family molecule and the amino acid sequence of the TRAF family molecule coded for by the above gene have been elucidated by conducting a polymerase chain reaction using cDNAs originating in various cell strains or tissues as the template by using an oligo-DNA primer which can amplify the best preserved domains among known TRAF family molecules. The TRAF family molecule, the gene and the antibody serve to provide means for elucidating the functions of the proteins and for elucidating the signal transducer system of a TNF-R family in which the molecule participates, to provide probes for research and diagnosis, and to indicate applications for therapeutic agents. <IMAGE>