发明名称 |
Nasal delivery of cyclodextrin complexes of anti-inflammatory steroids |
摘要 |
Aqueous, anti-inflammatory steroid compositions in solution form suitable for nasal administration and having a reduced stinging sensation are provided as well as a method for treating inflammation of the nasal mucosa by intranasal administration of anti-inflammatory steroid compositions. These solution compositions may result in enhanced nasal bio-availability. The anti-inflammatory steroid composition suitable for intranasal administration includes an anti-inflammatory steroid in an amount of from about 0.0001% to about 2.0% (w/v); a cyclodextrin in an amount of from about 0.1% to about 20% (w/v); an alcohol co-solvent in an amount of from about 0.2% to about 35% (w/v); a crystallization inhibitor where required, an effective amount of an antimicrobial preservative; an effective amount of an antioxidant; an effective amount of a chelating agent; water; and a pH adjusting agent sufficient to adjust the pH of the composition to from about 4 to about 7.
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申请公布号 |
US2006045850(A1) |
申请公布日期 |
2006.03.02 |
申请号 |
US20040930986 |
申请日期 |
2004.08.30 |
申请人 |
QPHARMA, LLC |
发明人 |
NAMBURI RANGA R.;JAGINI SUCHARITHA;PALKHIWALA BURGISE F. |
分类号 |
A61K31/724;A61K9/14;A61L9/04 |
主分类号 |
A61K31/724 |
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地址 |
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