MULTI-FUNCTIONAL BIOCOMPATIBLE COATINGS FOR INTRAVASCULAR DEVICES
摘要
A polymeric coating is adapted to substantially eliminate thrombus formation when in contact with blood. The polymeric coating includes a first polymeric layer and a second polymeric layer. Interposed between the first and second polymeric layers is a polymeric matrix layer doped with at least one of a nitric oxide donor and a nitric oxide generator. The nitric oxide donor and/or the nitric oxide generator are capable of releasing or generating NO. A bioactive agent is either immobilized to the surface of the second polymeric layer or is incorporated into the polymeric matrix layer.
申请公布号
WO2006023693(A2)
申请公布日期
2006.03.02
申请号
WO2005US29490
申请日期
2005.08.18
申请人
THE REGENTS OF THE UNIVERSITY OF MICHIGAN;MICHIGAN CRITICAL CARE CONSULTANTS, INC. (MC3);ZHOU, ZHENGRONG;MEYERHOFF, MARK, E.;REYNOLDS, MELISSA, M.
发明人
ZHOU, ZHENGRONG;MEYERHOFF, MARK, E.;REYNOLDS, MELISSA, M.