| 摘要 |
A biological sensor utilizing no label, such as a fluorescent material, and that does not require the setting of any marker to a sample. The sensor can make measurement easily and quickly. Molecules to be coupled with an object substance contained in a sample are oscillated, and state changes of the oscillating molecules are measured before and after the coupling, thereby measuring the weight of the object molecules. As a result, the influence of impurities that differ among oscillation states may be suppressed. Periodical signals caused by the oscillation of molecules are subjected to lock-in measurement to reduce the 1/f noise generated by the combination of the object substance with the receptor on the surface of a solid body to improve measurement sensitivity.
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