PRODUCTION AND CHARACTERISTICS OF ANTI-TEICOPLANIN POLYCLONAL ANTIBODY

摘要

The present invention also relates to anti-teicoplanin polyclonal antibodies raised against a composition comprising teicoplanin encapsulated in negatively-charged liposomes, said antibodies are not immunoreactive with any other antibiotics. The present invention also relates to a method for determining the amount of teicoplanin in a biological sample, which comprises the steps of a) incubating anti-teicoplanin antiserum of the present invention with a biological sample containing an unknown amount of teicoplanin on a solid support for a time sufficient to allow for an immunogenic reaction to occur; b) incubating anti-teicoplanin polyclonal antibodies of the present invention in serum with a standard containing a known amount of teicoplanin on a solid support for a time sufficient to allow for an immunogenic reaction to occur; and c) determining the presence or absence of agglutination in step a) and b) whereby determining said unknown amount of teicoplanin present in said biological sample by comparing with the complete inhibition of agglutination of step b).