发明名称 |
TRANSGENIC UNGULATES HAVING REDUCED PRION PROTEIN ACTIVITY AND USES THEREOF |
摘要 |
The invention provides cloned transgenic ungulates (e.g., bovines) in which prion protein activity is reduced by one or more genetically engineered mutations. Desirably, these transgenic bovines are also genetically modified to express xenogenous (e.g., human) antibodies. Because of their resistance to prion-related diseases such as bovine spongiform encephalopy (also known as mad cow disease), these bovines are a safer source of human antibodies for pharmaceutical uses and a safer source of agricultural products. |
申请公布号 |
EP1563084(A4) |
申请公布日期 |
2006.03.01 |
申请号 |
EP20030783271 |
申请日期 |
2003.11.10 |
申请人 |
HEMATECH, LLC;KIRIN BREWERY COMPANY LTD. |
发明人 |
ROBL, JAMES;KUROIWA, YOSHIMI;COLLAS, PHILIPPE;SULLIVAN, EDDIE;KASINATHAN, POOTHAPPILLAI;TOMIZUKA, KAZUMA;ISHIDA, ISAO |
分类号 |
A01K67/027;C07K16/00;C12N5/02;C12N5/07;C12N5/10;C12N5/12;C12N5/16;C12N15/00;C12N15/12;C12N15/85;C12P21/00;C12P21/08;C12Q1/68 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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