IMMUNOGENIC COMPOSITIONS COMPRISING VENEZUELAN EQUINE ENCEPHALITIS VIRUS REPLICON VECTORS AND PARAMYXOVIRUS PROTEIN ANTIGENS
摘要
<p>Self-propagating, fusogenic blebs are produced from cells infected with a population of Venezuelan Equine Encephalitis virus replicon particles (VRP). The self-propagating, fusogenic nature of the blebs is derived from expression of heterologous genes encoding viral fusion proteins that are incorporated into the replication defective replicon particles. The resulting blebs can be harvested from supernatants of cells displaying severe cytopathic effects. The blebs are used to make immunogenic compositions and devise methods of immunizing mammals against paramyxoviruses such as parainfluenza virus type 3.</p>
申请公布号
EP1629004(A1)
申请公布日期
2006.03.01
申请号
EP20040776196
申请日期
2004.06.02
申请人
WYETH HOLDINGS CORPORATION
发明人
KOVACS, GERALD, RAUL;MO, XIAOYAN;VASILAKIS, NIKOLAOS;BHARGAVA, SANGEETA;ZAMB, TIMOTHY, JOSEPH;UDEM, STEPHEN, ALEXANDER