发明名称 |
PHARMACEUTICAL CONTAINING 3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)PHENOL AND PROVIDING DELAYED RELEASE OF THE ACTIVE INGREDIENT |
摘要 |
A pharmaceutical formulation for delayed release of the active ingredient 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol or a pharmaceutically acceptable salt thereof in a matrix containing between 1 and 80 wt. % of at least one pharmaceutically acceptable hydrophilic or hydrophobic polymer as a matrix forming agent and exhibiting in vivo the following release rate: 3 to 35% by weight (based on 100% by weight active ingredient) 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 0.5 hours; 5 to 50% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 1 hour; 10 to 75% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 2 hours; 15 to 82% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 3 hours; 30 to 97% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 6 hours; more than 50% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 12 hours; more than 70% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 18 hours, and more than 80% by weight 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 24 hours. |
申请公布号 |
SI1439829(T1) |
申请公布日期 |
2006.02.28 |
申请号 |
SI20020030224T |
申请日期 |
2002.10.22 |
申请人 |
GRUENENTHAL GMBH |
发明人 |
BARTHOLOMAEUS JOHANNES;ZIEGLER IRIS |
分类号 |
A61K47/30;A61K9/20;A61K9/22;A61K9/50;A61K31/135;A61K31/136;A61K31/137;A61K47/38;A61P25/04 |
主分类号 |
A61K47/30 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|