| 摘要 |
biotechnology, more particularly of nucleic acids into cells. SUBSTANCE: in order to deliver nucleic acids, cell is maintained with compound having formula: w...x-y-NH-CR4(CH2OR1)(CH2OR2) wherein w is nucleic acid, x is peptide of amino acid, y is linker having chain which is equivalent to 1-20 carbon atoms or is not existent; R4 is H or CH2O-R3, and R1,R2 and R3 are identical or different and are either hydrogen, methyl, ethyl, hydroxy or acyl, group prepared from fatty acid having carbon chain containing 3-24 saturated or unsaturated carbon atoms provided that at least one radical R1, R2 and R3 is acyl group prepared from fatty acid or compound of formula (2): w...x-yNHCH2CH2OR5, wherein w is nucleic acid, x is peptide or amino acid, y is linker having chain which is equivalent to 1-20 carbon atoms, or it not existent, R5 is acyl group prepared from fatty acid having carbon chain containing 3-24 saturated or unsaturated carbon atoms. Invention makes it possible to deliver gene therapeutic drug into cells. EFFECT: more efficient of nucleic acids. 44 cl, 40 dwg, 4 tbl
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