| 摘要 |
Described is a compound of formula (I) and its use in the manufacture of a medicament to treat a disease state mediated by p38 kinase activity. R1 is selected from hydrogen, C1-6 alkyl optionally substituted, C2-6 alkenyl, C3-7 cycloalkyl and heteroaryl optionally substituted; R2 is selected from hydrogen, C1-6 alkyl and -(CH2)q-C3-7 cycloalkyl optionally substituted, or (CH2)mR1 and R2, together with the nitrogen atom to which they are bound, form a four- to six-membered heterocyclic ring optionally substituted; R3 is chloro or methyl; R4 is the group -NH-CO-R7 or CO-NH-(CH2)q-R8; X and Y are each independently selected from hydrogen, methyl and halogen; Z is halogen; m is selected from 0, 1, 2, 3 and 4; and n is selected from 0, 1 and 2. Also disclosed are the following processes for the preparation of the compound: (a) reacting a compound of formula (II) with a compound of formula (III); or (b) reacting a compound of formula (VIII) with a compound of formula (II) and then reacting the acid formed with an amine of formula (V); or (c) reacting a compound of formula (II) with a compound of formula (IX) in the presence of a catalyst.
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