| 摘要 |
A process for preparing a sterile ready-to-use aqueous pharmaceutical formulation comprising a high molecular weight hyaluronic acid salt (HA) at a specified concentration is disclosed, wherein the process comprises the steps of: providing an aqueous formulation comprising high molecular weight HA at a concentration of less than the specified final concentration; passing said aqueous formulation through a filter having a pore size less than 0.45 microns; concentrating said aqueous formulation by applying a vacuum and boiling off water until said specified concentration is reached.
|
