发明名称 |
VERFAHREN ZUR HERSTELLUNG VON 2-(-5-(4-FLUORPHENYL)-3-PYRIDYLMETHYLAMINOMETHYL)-CHROMAN |
摘要 |
The present invention relates to a process for the preparation of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, the enantiomers and its salts, characterised in that 5-(4-fluorophenyl)pyridine-3-carbaldehyde is reacted directly with aminomethylchroman or its salts under reducing conditions to give 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, and the latter is, if desired, converted into one of its physiologically acceptable salts by treatment with an acid. |
申请公布号 |
DE50204535(D1) |
申请公布日期 |
2006.02.23 |
申请号 |
DE2002504535 |
申请日期 |
2002.04.08 |
申请人 |
MERCK PATENT GMBH |
发明人 |
BOKEL, HEINZ-HERMANN;NEUNFELD, STEFFEN;GANTZERT, LUDWIG;KNIERIEME, RALF;SIMON, ELKE;DEVANT, RALF;HELM, UDO;REUBOLD, HELMUT |
分类号 |
C07D311/58;C07D405/12 |
主分类号 |
C07D311/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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