Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as CPLA2 inhibitors

摘要

The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: wherein R¹, R², R³, R⁴ and R⁵ are defined as described herein. The compound of formula 4 is then converted to the compound of formula 1. The invention further comprises compounds of formulas 3 and 4 and methods for making compounds of formulas 3 and 4.