发明名称 |
Use of enzyme inhibitors with aminopeptidase n and/or dipeptidylpeptidase IV activities and pharmaceutical preparations produced therefrom for the therapy and prevention of dermatological diseases with seborrhoeic hyperproliferation and altered differentiation states |
摘要 |
The invention relates to a process for the-inhibition of the DNA synthesis necessary for the proliferation of human sebaceous cells (sebocytes) by the isolated or joint effect of inhibitors of alanyl aminopeptidase (APN) and dipetidyl peptidase IV (DP IV) expressed by these cells. The DNA synthesis (proliferation) of human sebaceous cells is inhibited by the administration of the inhibitors of APN and/or of DP IV depending on the dose. Our invention shows that, for a therapy and for a prevention of dermatological diseases with sebaceous hyperproliferation and modified conditions of differentiation, the application of inhibitors of the above-mentioned enzymes and of corresponding pharmaceutical preparations and dosage forms thereof is suitable.
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申请公布号 |
US2006040850(A1) |
申请公布日期 |
2006.02.23 |
申请号 |
US20050507548 |
申请日期 |
2005.07.18 |
申请人 |
ANSORGE SIEGFRIED;GOLLNICK HARALD;NEUBERT KLAUS;ZOUBOULIS CHRISTOS;FAUST JURGEN;LENDECKEL UWE;REINHOLD DIRK;VETTER ROBERT |
发明人 |
ANSORGE SIEGFRIED;GOLLNICK HARALD;NEUBERT KLAUS;ZOUBOULIS CHRISTOS;FAUST JURGEN;LENDECKEL UWE;REINHOLD DIRK;VETTER ROBERT |
分类号 |
A61K38/04;C12N9/99;A61K31/195;A61K31/40;A61K31/426;A61K31/4453;A61K31/69;A61K38/55;A61K45/00;A61P17/00;A61P17/08;A61P17/10;A61P17/14;A61P35/00;A61P43/00 |
主分类号 |
A61K38/04 |
代理机构 |
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代理人 |
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