SEROTONIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL DISEASE

摘要

Treatment of diseases and disorders related to altered neuronal excitability, especially migraine prophylaxis, mood stabilisation and convulsions, in particular the treatment of convulsions due to epilepsy, also treatment of depression or psychomotor retardation in subjects prone to seizures. Serotonin receptor antagonists are employed, especially antagonists that are selective for 5-HT2 receptors, and ergolines, ergoline derivatives and analogues, in particular LY-53857.