DENDRITIC CELL VACCINES FOR TREATING CANCER MADE FROM EMBRYONIC STEM CELLS
摘要
This disclosure provides a technology for making a dendritic cell vaccine suitable for high volume manufacturing and distribution. Human stem cells are differentiated in a multi-step protocol to generate cell populations bearing a dendritic cell phenotype. The cells are loaded by pulsing with a specific tumor antigen, or by activation of an inducible transgene. The primed dendritic cells are powerful components of a vaccination strategy to elicit an immune response against tumor-associated antigens like telomerase. Vaccines and reagent combinations prepared according to this invention can be used on demand as off-the-shelf products for treating cancer.
申请公布号
WO2006020889(A2)
申请公布日期
2006.02.23
申请号
WO2005US28778
申请日期
2005.08.10
申请人
GERON CORPORATION;LEBKOWSKI, JANE, S.;MAJUMDAR, ANISH, SEN;STEMPEL, WILLIAM, D.;SCHIFF, J., MICHAEL
发明人
LEBKOWSKI, JANE, S.;MAJUMDAR, ANISH, SEN;STEMPEL, WILLIAM, D.;SCHIFF, J., MICHAEL