发明名称 |
Production of galactosylated glycoproteins in lower eukaryotes |
摘要 |
The present invention provides a novel lower eukaryotic host cell producing human-like glycoproteins characterized as having a terminal beta-galactose residue and essentially lacking fucose and sialic acid residues. The present invention also provides a method for catalyzing the transfer of a galactose residue from UDP-galactose onto an acceptor substrate in a recombinant lower eukaryotic host cell, which can be used as a therapeutic glycoprotein.
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申请公布号 |
US2006040353(A1) |
申请公布日期 |
2006.02.23 |
申请号 |
US20050108088 |
申请日期 |
2005.04.15 |
申请人 |
DAVIDSON ROBERT C;GERNGROSS TILLMAN U;WILDT STEFAN;CHOI BYUNG-KWON;NETT JUERGEN H;BOBROWICZ PIOTR;HAMILTON STEPHEN R |
发明人 |
DAVIDSON ROBERT C.;GERNGROSS TILLMAN U.;WILDT STEFAN;CHOI BYUNG-KWON;NETT JUERGEN H.;BOBROWICZ PIOTR;HAMILTON STEPHEN R. |
分类号 |
C07H21/04;C12N1/18;C12N9/10;C12N15/74;C12P19/28;C12P21/06 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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地址 |
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