PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS
摘要
Pre-treatment with one or more compounds of formula (I), as described herein, protects normal cells from the toxic side effects of ionizing radiation. Administration of one or more radioprotective compounds of formula I to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of one or more compounds of formula I allows for the safe increase the dosage of anticancer radiation. Amelioration of toxicity following inadvertent radiation exposure may also be mitigated with administration of one or more compounds of formula (I).
申请公布号
WO2005065074(A3)
申请公布日期
2006.02.23
申请号
WO2004US28654
申请日期
2004.09.02
申请人
TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;REDDY,E, PREMKUMAR;REDDY, M., V., RAMANA;COSENZA, STEPHEN, C.;GUMIREDDY, KIRANMAI
发明人
REDDY,E, PREMKUMAR;REDDY, M., V., RAMANA;COSENZA, STEPHEN, C.;GUMIREDDY, KIRANMAI