| 发明名称 |
POLYPEPTIDES AND ANTIBODIES DERIVED FROM CHRONIC LYMPHOCYTIC LEUKEMIA CELLS AND USES THEREOF |
| 摘要 |
An isolated antibody, or a CD200-binding fragment thereof, comprising at least one antigen binding site that binds to human CD200 (hCD200), wherein the antibody or CD200-binding fragment thereof is a humanized, fully human, or chimeric antibody or CD200-binding fragment thereof, and wherein a Fab fragment of the antibody inhibits the interaction between hCD200 and hCD200 receptor by at least 90% at a concentration of 6.7 µg/ml. as evaluated in an in vitro fluorescent microsphere assay.
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| 申请公布号 |
CA2777686(A1) |
申请公布日期 |
2006.02.23 |
| 申请号 |
CA20052777686 |
申请日期 |
2005.07.19 |
| 申请人 |
ALEXION PHARMACEUTICALS, INC. |
发明人 |
BOWDISH, KATHERINE S.;KRETZ-ROMMEL, ANKE;MCWHIRTER, JOHN;MARUYAMA, TOSHIAKI |
| 分类号 |
C07K16/28;A61K39/395;A61P35/00;A61P35/02;C07K14/705;C07K16/46;C12Q1/68;G01N33/48;G01N33/574 |
主分类号 |
C07K16/28 |
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