Substituted N-arylsulfonylheterocyclic amines as gamma-secretase inhibitors

摘要

This invention discloses novel gamma secretase inhibitors of the formula: wherein: L is -O-, -N(R⁶)-, -S-, -S(O)-, or -S(O₂)-; R¹ is selected from the group consisting of aryl and heteroaryl; R² is selected from the group consisting of alkyl, -C(O)-Y, -X-C(O)-Y, -alkylene-X-C(O)-Y, -alkylene-C(O)-Y, -alkylene-cycloalkylene-X-C(O)-Y, -alkylene-cycloalkylene-C(O)-Y, -cycloalkylene-alkylene-X-C(O)-Y, -cycloalkylene-alkylene-C(O)-Y, -cycloalkylene-X-C(O)-Y, -cycloalkylene-C(O)-Y, -alkylene-cycloalkylene-alkylene-X-C(O)-Y, -alkylene-cycloalkylene-alkylene-C(O)-Y, aryl, and heteroaryl; R³ is selected from the group consisting of aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, and alkoxyalkyl; each R⁴ and R⁵ is independently selected from the group consisting of H and alkyl; and Y is selected from the group consisting of -NR⁸R⁹, -N(R⁶)-(CH₂)_b-NR⁸R⁹, aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, and arylheterocycloalkyl; or Y is selected from the group consisting of: One or more compounds of formula I, or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.