THREE-DIMENSIONAL STRCTURE OF THE HUMAN ASPARTYL PROTEASE BETA-SITE AMYLOID PRECURSOR-PROTEIN-CLEAVING ENZYME 2 (BACE2), METHODS AND USE THEREOF

摘要

The present invention concerns the aspartyl protease beta-site amyloid precursor protein­cleaving enzyme 2 (BACE2), in particular, the three-dimensional structure of BACE2. Methods of expression, purification and crystallization of BACE2 are provided in preparation for crystallography. The atomic coordinates of a complex of BACE2 complexed with an inhibitor are also provided.