CELL-BASED THERAPIES FOR DIABETES MELLITUS AND OTHER GLUCOSE INTOLERANT STATES
摘要
The present invention provides cells comprising an isolated nucleic acid encoding a novel lactate dehydrogenase (LDH) and/or the encoded LDH polypeptide. The invention further provides cells comprising an isolated nucleic acid encoding LDH, wherein the cell is capable of producing and secreting insulin. Also provided are methods of providing fuel-stimulated (e.g., glucose-stimulated) insulin secreting capability to a mammalian subject by implanting cells of the invention (e.g., in a semi-permeable membrane and/or an implantable device) into the subject. Further provided are devices comprising the cells of the invention. In particular embodiments, the device is an implantable device.
申请公布号
WO2004065552(A3)
申请公布日期
2006.02.23
申请号
WO2004US01451
申请日期
2004.01.21
申请人
DUKE UNIVERSITY;BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM;NEWGARD, CHRISTOPHER, B.;JENSEN, METTE, V.;SHERRY, A., DEAN;BURGESS, SHAWN, C.
发明人
NEWGARD, CHRISTOPHER, B.;JENSEN, METTE, V.;SHERRY, A., DEAN;BURGESS, SHAWN, C.