Process for preparing of Paclitaxel

摘要

A process for making paclitaxel comprises: (a) acetylating 10-deacetyl baccatin-III at the C-10 position in the presence of a tertiary amine base to give baccatin-III; (b) protecting baccatin-III at the C-7 position by reacting baccatin-III with a protecting group; (c) converting the product of step (b) to paclitaxel. Preferably, the protecting group at the C-7 position is 2,2,2- trichloroethylchloroformate.