发明名称 |
PROCESSES FOR PRODUCING PYRAZOLOACRIDONE DERIVATIVE AND INTERMEDIATE THEREFOR |
摘要 |
<p>
(wherein R represents lower alkyl; R 1 represents a hydrogen atom, -CH 2 X or -OC(=O)R 3 ; and R 2 represents a hydrogen atom, nitro, halogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkylthio or substituted or unsubstituted aryl) The present invention provides a simple industrial process for producing pyrazoloacridone derivatives having an antitumor activity, 1-(2-carboxyphenyl)indazole derivatives, which are useful as synthetic intermediates thereof, or the like; and the like. For example, the present invention provides a process for producing a 1-(2-carboxyphenyl)indazole derivative represented by general formula (IV) which comprises steps of reacting a compound represented by above general formula (I) with a compound represented by above general formula (II) in the presence of a base to produce a compound represented by above general formula (III); and hydrolyzing a cyano group of the resulting compound represented by general formula (III).</p> |
申请公布号 |
EP1627877(A1) |
申请公布日期 |
2006.02.22 |
申请号 |
EP20040729194 |
申请日期 |
2004.04.23 |
申请人 |
KYOWA HAKKO KOGYO CO., LTD. |
发明人 |
TSUBAKIHARA, NOBUAKI;KATSUHIRA, TAKESHI;KINUGAWA, MASAHIKO;KATO, NOBUYUKI |
分类号 |
C07D231/56;C07D231/54;C07D471/06;(IPC1-7):C07D471/06 |
主分类号 |
C07D231/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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