发明名称 |
Method for the production of crystals, crystals obtained by said method, and use thereof in pharmaceutical formulations. |
摘要 |
The process for making crystals of a 11 beta-benzaldoxim-estra-4,9-diene derivative having an average particle size of from 3 mum to 25 mum and a maximum particle size of 100 mum, includes subjecting a supersaturated solution containing a special 11beta-benzaldoxim-estra-4,9-diene derivative of formula (I) to a wet milling by a wet milling apparatus while crystallizing, In order to obtain a primary particle suspension. Crystals obtained according to this process and pharmaceutical preparations containing them are also described and are part of the invention. |
申请公布号 |
ZA200409395(B) |
申请公布日期 |
2006.02.22 |
申请号 |
ZA20040009395 |
申请日期 |
2004.11.22 |
申请人 |
SCHERING AG. |
发明人 |
DETLEF GRAWE;PETER HOESEL;SABINE GLIESING;HAGEN GERECKE;ANNETTE EICHARDT;UWE MUELLER |
分类号 |
A61K9/14;A61K31/569;A61P5/24;A61P15/00;A61P15/18;A61P17/02;A61P35/00;C07J41/00 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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