发明名称 |
Clarithromycin formulations having improved biovailability. |
摘要 |
A pharmaceutical composition includes micronized clarithromycin and exhibits improved dissolution characteristics relative to a pharmaceutical composition that includes unmicronized clarithromycin. The clarithromycin may have a particle size less than approximately 35 microns. One process for preparing an extended release tablet of the clarithromycin includes micronizing the clarithromycin; blending the micronized clarithromycin with one or more rate controlling polymers and pharmaceutically acceptable excipients; granulating the blend; and compressing to form a tablet. To treat a bacterial infection in a mammal in need of treatment, a patient may be administered a pharmaceutical composition that includes micronized clarithromycin. |
申请公布号 |
ZA200408568(B) |
申请公布日期 |
2006.02.22 |
申请号 |
ZA20040008568 |
申请日期 |
2004.10.22 |
申请人 |
RANBAXY LABORATORIES LIMITED |
发明人 |
ASHOK RAMPAL;RAGHUVANSHI, RAJEEV, S.;MANOJ KUMAR PARUTHI |
分类号 |
A61K9/14;A61K9/20;A61K31/7048 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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