发明名称 |
Microspheres for use in the treatment of cancer |
摘要 |
The subject invention pertains to novel materials and methods for use in treating patients afflicted with oncological disorders, such as tumors. One aspect of the invention concerns methods for treating tumors comprising the administration of drug loaded pH-sensitive microspheres to a patient in need of anticancer therapy. The pH-sensitive microspheres have a swelling transition with the pH range found in or near tumor tissue. When the microspheres swell, the loaded drug is released into the microenvironment of the tumor tissue. The subject invention also pertains to novel microspheres useful in the methods of the invention. The microspheres are capable of effectively releasing a loaded substance at a predetermined pH. The subject invention also concerns novel methods for synthesizing the microspheres of the present invention.
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申请公布号 |
US7001616(B2) |
申请公布日期 |
2006.02.21 |
申请号 |
US20030431833 |
申请日期 |
2003.05.08 |
申请人 |
UNIVERSITY OF FLORIDA |
发明人 |
BATICH CHRISTOPHER D.;LECKEY ADAM;VAUTHEY J. NICOLAS |
分类号 |
A61K9/14;A61K9/06;A61K9/16;A61K9/50;A61K51/00;A61K51/12 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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