RECESSIVE DIVIDING RETROVIRAL VECTOR (VARIANTS), METHOD FOR PRODUCTION THEREOF (VARIANTS), ISOLATED AND PURIFIED NUCLEIC ACID MOLECULE

摘要

FIELD: biotechnology, medicine, in particular viral disease treatment. ^ SUBSTANCE: invention relates to recessive dividing retroviral vector useful in inhibition of wild-type retrovirus replication. Vector contains retroviral long terminal repeat sequences; retroviral packing signal; nucleotide sequence encoding (expressing) genetic antiviral agent; and optionally the second nucleotide sequence. Disclosed are method for production of said vector and reproduction thereof. Further isolated and purified nucleic acid (NA) molecule providing of selective advantage in regard to viral generation packing into virions is disclosed. Uses of retroviral vector in particular for specific antibody production are described. ^ EFFECT: new genetic antiviral agents generating prolonged and stable immunological responses in regard, for example, to AIDS and cancer viruses. ^ 97 cl, 11 ex