摘要 |
The invention provides a drug which inhibits BCRP. A breast cancer resistance protein inhibitor containing, as an active ingredient, a diphenylacrylonitrile derivative represented by the following formula (1): [wherein, each of 8 R's, which are the same or different from one another, represents a hydrogen atom, a hydroxyl group, a nitro group, an amino group, an acetylamino group (-NHCOCH<SUB>3 </SUB>group); a cyano group (-CN group); a formyl group (-CHO group), -COOR<SUB>1 </SUB>(R<SUB>1 </SUB>is hydrogen or C1-C4 alkyl), -O(CH<SUB>2</SUB>)<SUB>n</SUB>COOR<SUB>2 </SUB>(n=1-7: R<SUB>2 </SUB>is hydrogen or C1-C4 alkyl), -OOCCH<SUB>2</SUB>CH<SUB>2</SUB>COOR<SUB>3 </SUB>(R<SUB>3 </SUB>is hydrogen, C1-C4 alkyl, (Z)-2-(3,4-dimethoxy-phenyl)-3-(4-hydroxy-phenyl)-acrylonitrile, or glycopyranosyl), a C1-C8 alkoxy group, a C1-C4 alkyl group, a halogen atom, a C1-C4 alkoxy C1-C4 alkoxy C1-C4 alkoxy group, a C2-C8 acyloxy group, a C2-C8 halogenoacyloxy group, a methylenedioxy group, a trifluoromethyl group, a phosphate group (i.e., -OP(O) (OH)<SUB>2</SUB>) or a salt thereof, a sulfate group (i.e., -OSO<SUB>3</SUB>H) or a salt thereof, a glycopyranosyl group or a salt thereof, a phosphate ester of a glycopyranosyl group or a salt of the ester, a sulfate ester of a glycopyranosyl group or a salt of the ester, or a piperidinopiperidinocarbonyloxy group], an ester thereof, or a salt thereof. |