| 摘要 |
Acylated aminopropane diols and their analogs (I), their optical and geometric isomers, racemates, salts, and mixtures. Acylated aminopropane diols and their analogs (I), their optical and geometric isomers, racemates, salts, and mixtures [Image] G2, G3 : O, S, or N-R4, with the proviso that they are not both N-R4; R, R4 : H, optionally saturated and optionally substituted 1-5C alkyl; R1, R2, R3 : H, CO-R5, or CO-(CH 2) 2 n + 1-X-R6, at least one of these being CO-(CH 2) 2 n + 1-X-R6; R5 : optionally saturated and optionally substituted alkyl, that may contain a cyclic group and having 1-25C atoms in the main chain; X : S, Se, SO, or SO 2; n : 0 - 11; R6 : optionally saturated and optionally substituted alkyl, that may contain a cyclic group and one or more hetero groups (O, S, Se, SO or SO 2) and having 3-23C atoms in the main chain with the exclusion of those compounds of formula (I) in which G2R2 and G3R3 are both OH groups. ACTIVITY : Cerebroprotective. MECHANISM OF ACTION : Peroxisome Proliferator-Activated Receptor activators. |
