摘要 |
FIELD: organic chemistry, chemical technology, medicine. ^ SUBSTANCE: invention proposes a method for preparing 5-aminolevulinic acid (ALA) alkyl esters and their hydrochlorides. Method for preparing ALA alkyl ester hydrochlorides involves the esterification reaction of ALA hydrochloride with primary or secondary (C1-C6)-alcohols in the presence of a heterogenous acid catalyst wherein cation-exchange resins in H+-form can be used as a catalyst with their preliminary dehydration by thermal treatment or azeotropic distillation off. Invention provides preparing indicated compounds by development of ecologically safe, technologically effective and economy method. ALA alkyl esters are used in fluorescent diagnosis and photodynamic therapy of malignant tumors of different localization and in treatment of cutaneous diseases of nontumor nature. ^ EFFECT: improved preparing method. ^ 7 ex |