发明名称 |
Vandig dispersion, der omfatter stabile nanopartikler af et vanduoplöseligt aktivt stof og en excipiens som middellangkædede triglycerider (MCT) |
摘要 |
A process for the preparation of a stable dispersion of solid particles, in an aqueous medium comprising combining (a) a first solution comprising a substantially water-insoluble substance, a water-miscible organic solvent and an inhibitor with (b) an aqueous phase comprising water and optionally a stabiliser, thereby precipitating solid particles comprising the inhibitor and the substantially water-insoluble substance; and optionally removing the water-miscible organic solvent; wherein the inhibitor is a non-polymeric hydrophobic organic compound as defined in the description. The process provides a dispersion of solid particles in an aqueous medium, which particles exhibit reduced or substantially no particle growth mediated by Ostwald ripening. |
申请公布号 |
DK1416917(T3) |
申请公布日期 |
2007.09.17 |
申请号 |
DK20020745697T |
申请日期 |
2002.08.01 |
申请人 |
ASTRAZENECA AB |
发明人 |
OLSSON, ULF;SKANTZE, TOMMY, URBAN;LINDFORS, PER, LENNART;VON CORSWANT, LARS, CHRISTIAN;ZZACKRISSON SCHANTZ, ANNA, ELISABETH;SKANTZE, PIA, MARGARETHA, CECILIA |
分类号 |
A61K9/10;A61K9/16;A61K9/51;A61K47/10;A61K47/14;A61K47/44 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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